DistillPath-IS16-HOpt0
A 22M ViT-S/16 pathology tile encoder distilled from H-optimus-0 (1.1B ViT-g/14) into an ImageNet-21k pretrained ViT-S/16 student using backbone-token distillation on 6,000 public TCGA slides.
This is the ImageNet-initialized variant. For the stronger kaiko-initialized variant, see DistillPath-KS16-HOpt0.
Paper: DistillPath: An Efficient 22M Distilled Pathology Encoder Approaching Large Foundation Model Performance Ramon Kaspar, Andrey Ignatov, Valentina Boeva. ETH Zurich. Published at the ECCV 2026 Workshop on Medical Foundation Models and Benchmarks (MedFM-Bench).
Model details
| Property | Value |
|---|---|
| Architecture | ViT-S/16 (vit_small_patch16_224 in timm) |
| Parameters | 21.7M |
| Feature dimension | 384 |
| Input size | 224 x 224 |
| Normalization | mean=(0.485, 0.456, 0.406), std=(0.229, 0.224, 0.225) |
| Student initialization | ImageNet-21k ViT-S/16 |
| Teacher | H-optimus-0 (1.1B, ViT-g/14, Apache 2.0) |
| Training data | 6,000 TCGA H&E whole-slide images, 32 cohorts |
| Training steps | 50,000 (batch size 256) |
Benchmark results
| Benchmark | DistillPath-IS16-HOpt0 | IN21K baseline | H-optimus-0 teacher |
|---|---|---|---|
| EVA mean (7 tasks) | 0.768 | 0.729 | 0.803 |
| HEST mean (9 tasks) | 0.363 | 0.311 | 0.415 |
| PLISM score | 0.526 | 0.383 | 0.480 |
See the paper for per-task results.
Usage
Load directly from the Hub with timm:
import timm
model = timm.create_model(
"hf_hub:RamonK/DistillPath-IS16-HOpt0",
pretrained=True,
num_classes=0,
)
model.eval()
Or load manually:
import timm
from huggingface_hub import hf_hub_download
from safetensors.torch import load_file
model = timm.create_model("vit_small_patch16_224", pretrained=False, num_classes=0)
path = hf_hub_download("RamonK/DistillPath-IS16-HOpt0", "model.safetensors")
state_dict = load_file(path)
model.load_state_dict(state_dict, strict=True)
model.eval()
This model uses ImageNet normalization: mean=(0.485, 0.456, 0.406), std=(0.229, 0.224, 0.225).
from torchvision import transforms
transform = transforms.Compose([
transforms.Resize(224),
transforms.CenterCrop(224),
transforms.ToTensor(),
transforms.Normalize(mean=[0.485, 0.456, 0.406], std=[0.229, 0.224, 0.225]),
])
Distillation recipe
The recipe reads only the teacher's final class and patch tokens (no teacher pretraining heads required):
- Class-token loss: cosine distance + RKD (relational knowledge distillation)
- Patch-token loss: cosine distance after bicubic grid resizing (teacher 16x16 to student 14x14)
- Optimizer: AdamW, lr=1e-4, weight decay 0.05, cosine decay, 500 warmup steps
- Projector: DINO-style MLP (384 to 2048 to 2048 to 256 to d_t), discarded after training
Full details in the paper and the DistillPath repository.
License
This model is released under the Apache 2.0 License. Both the student (ImageNet-21k ViT-S/16) and teacher (H-optimus-0) are Apache 2.0, so this model is fully permissive, including for commercial use.
Citation
@inproceedings{kaspar2026distillpath,
title = {DistillPath: An Efficient 22M Distilled Pathology Encoder Approaching Large Foundation Model Performance},
author = {Kaspar, Ramon and Ignatov, Andrey and Boeva, Valentina},
booktitle = {Medical Foundation Models and Benchmarks (MedFM-Bench), ECCV 2026},
year = {2026}
}