PoreCodec-RSQ742C12A

PoreCodec-RSQ742C12A is a lightweight neural codec for nanopore electrical signals. It converts continuous ionic current measurements into compact hierarchical discrete token sequences using a convolutional encoder followed by a production-oriented Residual Finite Scalar Quantization (Residual FSQ) module.

Unlike traditional VQ-VAE based codecs, PoreCodec employs deterministic finite scalar quantization with exhaustive codebooks stored directly inside the model checkpoint, eliminating codebook collapse while enabling efficient constant-time decoding.

The resulting discrete representations are designed to serve as the interface between raw nanopore signals and transformer-based foundation models.

Highlights

• Production-ready neural codec for nanopore signals
• Lightweight fully convolutional encoder/decoder
• Residual Finite Scalar Quantization (Residual FSQ)
• Exhaustive codebooks stored inside safetensors
• Constant-time O(1) decoding lookup
• Hierarchical discrete token generation
• HuggingFace AutoModel compatible
• End-to-end signal reconstruction
• Foundation-model friendly discrete representation

Architecture

Raw Nanopore Signal
        │
        ▼
 CNN Encoder
        │
        ▼
512-D Latent Features
        │
        ▼
Linear Projection
        │
        ▼
Residual Finite Scalar Quantization
        │
        ├──────────────► Hierarchical Token IDs
        │
        ▼
Quantized Latent Features
        │
        ▼
Linear Projection
        │
        ▼
 CNN Decoder
        │
        ▼
Reconstructed Signal

The model consists of three major components:

CNN Encoder

The encoder extracts local electrical signal patterns through a deep one-dimensional convolutional network.

The encoder transforms raw nanopore current measurements into compact latent representations while preserving local temporal structures.

Residual Finite Scalar Quantization

Instead of learning vector codebooks as in conventional VQ-VAE methods, PoreCodec performs deterministic residual scalar quantization over a finite Cartesian lattice.

Each residual stage quantizes the reconstruction error produced by previous stages, progressively refining the latent representation.

Unlike learned vector quantizers:

• no codebook collapse
• no dead entries
• deterministic encoding
• stable optimization
• exact reconstruction lookup

All exhaustive codebooks are precomputed and stored directly inside the model checkpoint, allowing constant-time lookup during decoding.

Quantization Configuration

Hierarchical Tokens

Each latent position produces multiple residual quantization indices

Latent Vector

↓

Residual Quantizer 1

↓

Residual Quantizer 2

↓

Level Indices

↓

Unified Token IDs

Different hierarchy depths may be selected:

Higher layers generally provide improved reconstruction quality at the expense of larger token vocabulary.

Signal Preprocessing

The accompanying FeatureExtractor performs automatic preprocessing before inference.

Pipeline:

1. Physical boundary correction
2. Spike removal
3. Median-MAD normalization
4. Optional median filtering
5. Smooth nonlinear clipping

Available preprocessing strategies:

apple (default)

• Error repair
• Spike removal
• Median-MAD normalization
• Median filtering
• Smooth clipping

mongo

• Error repair
• Spike removal
• Median-MAD normalization
• Smooth clipping

Quick Start

import numpy as np
from transformers import AutoFeatureExtractor, AutoModel

model_name = "ShuaiAnwo/pore-codec-rsq742c12a-513"

feature_extractor = AutoFeatureExtractor.from_pretrained(
    model_name,
    trust_remote_code=True,
)

model = AutoModel.from_pretrained(
    model_name,
    trust_remote_code=True,
)

model.eval()

raw_signal = np.random.normal(
    loc=70,
    scale=8,
    size=1855,
).astype(np.float32)

signal = feature_extractor(
    raw_signal,
    return_tensors="pt",
)["signal"]

token_ids = model.encode_signal(
    signal,
    layer=2,
)

reconstructed = model.decode_token(
    token_ids,
    layer=2,
)

API

encode_signal

Convert normalized nanopore signals into discrete token IDs.

token_ids = model.encode_signal(signal, layer=2)

Returns

[B, N]

decode_token

Reconstruct signals directly from token IDs.

reconstructed = model.decode_token(
    token_ids,
    layer=2,
)

forward

Complete end-to-end codec inference.

reconstruction, level_indices = model(signal)

Returns

• reconstructed signal
• hierarchical residual indices

tokenize_indices

Convert hierarchical residual indices into unified token IDs.

token_ids = model.tokenize_indices(
    level_indices,
    layer=2,
)

decode_indices

Reconstruct signals directly from residual indices.

signal = model.decode_indices(
    level_indices,
    layer=2,
)

Model Configuration

Applications

PoreCodec may be used for

• Nanopore signal tokenization
• Neural signal compression
• Foundation models for nanopore sequencing
• Biological representation learning
• Retrieval and indexing of nanopore reads
• Token-based pretraining
• Generative modeling over nanopore signals

Advantages over Conventional VQ

Limitations

This model is designed for nanopore electrical current signals after preprocessing by the accompanying FeatureExtractor.

It is not intended for direct basecalling or DNA sequence prediction.

Citation

If you use PoreCodec in your research, please cite:

@misc{jiao2026porecodec,
  title={PoreCodec: Residual Finite Scalar Quantization for Nanopore Signal Tokenization},
  author={Shuai Jiao},
  year={2026}
}

License

Released under the Apache-2.0 License.