Plant foundation DNA large language models
The plant DNA large language models (LLMs) contain a series of foundation models based on different model architectures, which are pre-trained on various plant reference genomes.
All the models have a comparable model size between 90 MB and 150 MB, BPE tokenizer is used for tokenization and 8000 tokens are included in the vocabulary.
Developed by: zhangtaolab
Model Sources
- Repository: Plant DNA LLMs
- Manuscript: Versatile applications of foundation DNA language models in plant genomes
Architecture
The model is trained based on the InstaDeepAI/nucleotide-transformer-v2-100m-multi-species model with modified tokenizer that replaces k-mer to BPE.
How to use
Install the runtime library first:
pip install transformers
Here is a simple code for inference:
from transformers import AutoModelForMaskedLM, AutoTokenizer
import torch
model_name = 'plant-nucleotide-transformer-BPE'
# load model and tokenizer
model = AutoModelForMaskedLM.from_pretrained(f'zhangtaolab/{model_name}', trust_remote_code=True)
tokenizer = AutoTokenizer.from_pretrained(f'zhangtaolab/{model_name}', trust_remote_code=True)
# example sequence and tokenization
sequences = ['ATATACGGCCGNC','GGGTATCGCTTCCGAC']
tokens = tokenizer(sequences,padding="longest")['input_ids']
print(f"Tokenzied sequence: {tokenizer.batch_decode(tokens)}")
# inference
device = torch.device('cuda') if torch.cuda.is_available() else torch.device('cpu')
model.to(device)
inputs = tokenizer(sequences, truncation=True, padding='max_length', max_length=512,
return_tensors="pt")
inputs = {k: v.to(device) for k, v in inputs.items()}
outs = model(
**inputs,
output_hidden_states=True
)
# get the final layer embeddings and prediction logits
embeddings = outs['hidden_states'][-1].detach().numpy()
logits = outs['logits'].detach().numpy()
Training data
We use MaskedLM method to pre-train the model, the tokenized sequence have a maximum length of 512.
Detailed training procedure can be found in our manuscript.
Hardware
Model was pre-trained on a NVIDIA RTX4090 GPU (24 GB).